{"id":112207,"date":"2025-09-28T07:45:53","date_gmt":"2025-09-28T11:45:53","guid":{"rendered":"https:\/\/www.sharpfootballanalysis.com\/?p=112207"},"modified":"2025-09-29T09:37:12","modified_gmt":"2025-09-29T13:37:12","slug":"nfl-week-4-predictions-picks-best-bets-odds-spread-ats-today-this-week-2025","status":"publish","type":"post","link":"https:\/\/www.sharpfootballanalysis.com\/betting\/nfl-week-4-predictions-picks-best-bets-odds-spread-ats-today-this-week-2025\/","title":{"rendered":"NFL Best Bets: Week 4 Predictions &#038; Against The Spread Picks"},"content":{"rendered":"<p>Week 4 of the 2025 NFL season is here!<\/p>\n<p>There are great matchups throughout the slate, but let's focus on the Chargers taking on the Giants and the Panthers traveling to New England.<\/p>\n<h2>Week 4 Prediction: Los Angeles Chargers Team Total Over 24.5 Points (-112)<\/h2>\n<p>The Chargers hung 27 points on the Chiefs in Brazil in Week 1, but they haven\u2019t cleared their team total of 24.5 points for this week in two subsequent contests, scoring 20 against the Raiders in Las Vegas on Monday Night Football in Week 2 and 23 at home against the Broncos in Week 3.<\/p>\n<p>Still, Los Angeles\u2019s offense has been rock-solid, and <strong>Justin<\/strong> <strong>Herbert<\/strong> has played at a high level this season.<\/p>\n<p>According to Pro Football Reference, the Chargers are 10th in yards per play (5.5) and tied for 14th in scoring offense (23.3 points per game).<\/p>\n<p>Their underlying data is even better.<\/p>\n<p>According to Sumer Sports, the Chargers are tied for ninth in expected points added (EPA) per play (0.05) and eighth in success rate (45.18%).<\/p>\n<p>Furthermore, the offense is flowing through Herbert. Per nfelo, the Chargers have an NFL-high 8.8% pass rate over expectations (PROE) this season.<\/p>\n<p>Herbert is rewarding head coach <strong>Jim<\/strong> <strong>Harbaugh<\/strong> and offensive coordinator <strong>Greg<\/strong> <strong>Roman<\/strong> for their faith in him.<\/p>\n<p>Herbert is fifth in EPA this season.<\/p>\n<p>In addition, among 34 quarterbacks with at least 40 dropbacks this year, Herbert has Pro Football Focus\u2019s (PFF\u2019s) eighth-highest passing grade.<\/p>\n<p>Herbert and the Chargers shouldn\u2019t find the sledding tough against the Giants.<\/p>\n<p>Big Blue is tied for the ninth-most yards per play (5.7) allowed this year, and they\u2019ve permitted the ninth-most points per game (27.7).<\/p>\n<p>The advanced metrics for the G-Men\u2019s defense are even more damning.<\/p>\n<p>They\u2019ve allowed the third-most EPA per play (0.13) and the fourth-highest success rate (47.91%).<\/p>\n<p>The Chargers should have no problem marching up and down the field against New York\u2019s defense.<\/p>\n<p>Can the Giants push back enough for the Chargers to clear 24.5 points this week? They might be able to.<\/p>\n<p>Yet, even if the Giants don\u2019t put up much of a fight, they\u2019ll likely at least do it quickly after promoting rookie <strong>Jaxson<\/strong> <strong>Dart<\/strong> to starting quarterback duties.<\/p>\n<p>Josh Norris and Hayden Winks from Underdog Fantasy discussed the Giants playing more aggressively and faster with Dart in the preseason on their most recent <a href=\"https:\/\/youtu.be\/0OuMZLTxzHA?si=3Jgbn3w_iTKQunR_\">Stats versus Film episode<\/a>.<\/p>\n<p>If <strong>Brian<\/strong> <strong>Daboll<\/strong> and <strong>Mike Kafka<\/strong> call a fast and aggressive offense with Dart at the helm, there are multiple positive avenues for the Chargers to score points.<\/p>\n<p>First, Dart can push them by scoring points, forcing the Chargers to keep their foot on the accelerator.<\/p>\n<p>Second, he could turn the ball over on downs quickly. Therefore, the Giants wouldn\u2019t use a lot of clock before giving the ball back to the Chargers.<\/p>\n<p>Third, a rookie quarterback playing fast and aggressively in his first professional start could turn the ball over against <strong>Jesse Minter<\/strong>\u2019s defense, potentially awarding the Chargers short fields and more quick-scoring opportunities.<\/p>\n<p>Any of those three outcomes would help the Chargers exceed 24.5 points.<\/p>\n<p>I expect Los Angeles to go over their team total, and the -112 line for over 24.5 points at DraftKings Sportsbook is the best value across sportsbooks since it is 1 point lower than at some other sites.<\/p>\n<p><strong>Don't Miss Out on the Best Betting Recommendations Available<\/strong><\/p>\n<p><em>Warren Sharp is entering his 20th year providing winning betting recommendations to clients.<br \/>\n<\/em><\/p>\n<p><em>He has hit on 57% of his lifetime college recommendations, including 73% of his top selections.<\/em><\/p>\n<p><em>A $100 bettor was up\u00a0<strong>$15,636<\/strong>\u00a0following Warren\u2019s picks for both college and the NFL last season.<\/em><\/p>\n<p><em><a href=\"https:\/\/www.sharpfootballanalysis.com\/betting-fantasy-props-combo-packages\/?utm_source=site&utm_medium=article-text\"><strong>Click here to learn more about 2025 Betting Packages!<\/strong><\/a><\/em><\/p>\n<h2>Week 4 Prediction: Carolina Panthers Team Total Under 18.5 Points (-105)<\/h2>\n<p>The Panthers have cleared 18.5 points in back-to-back games after scoring only 10 in Jacksonville in a Week 1 loss.<\/p>\n<p>Conversely, the Patriots have surrendered more than 18.5 points in all three games this season, permitting 20 to the Raiders at home in Week 1, 27 to the Dolphins in Miami in Week 2, and 21 to the Steelers in New England in Week 3.<\/p>\n<p>Expecting the Patriots to deliver their best defensive performance of the year and hold the Panthers to fewer than 18.5 points might feel ambitious.<\/p>\n<p>However, there are contextual and statistical reasons to think Carolina won\u2019t clear 18.5 points this week.<\/p>\n<p>First, the injury factors should work in New England\u2019s favor.<\/p>\n<p>Lockdown stud cornerback <strong>Christian Gonzalez<\/strong> hasn\u2019t suited up for the Patriots yet this season.<\/p>\n<p>Gonzalez didn\u2019t practice at all with a hamstring injury through the first two weeks of the season.<\/p>\n<p>However, he was a limited participant in every practice last week before ultimately getting ruled out, and he\u2019s started this week with a limited participation designation.<\/p>\n<p>Among 88 cornerbacks with at least 350 coverage snaps last season, Gonzalez had PFF\u2019s 10th-highest coverage grade and allowed the fourth-lowest quarterback rating (70.5) on targets in his direction.<\/p>\n<p>Again, Gonzalez is a game-changing talent.<\/p>\n<p>Meanwhile, the Panthers are the walking wounded.<\/p>\n<p>Carolina\u2019s starting center, <strong>Austin<\/strong> <strong>Corbett<\/strong>, and starting guard, <strong>Rob<\/strong> <strong>Hunt<\/strong>, were placed on injured reserve after they suffered significant injuries in Week 2.<\/p>\n<p>Tight end <strong>Ja\u2019Tavion Sanders<\/strong> is week-to-week with a high-ankle sprain, and their talented rookie No. 1 wideout <strong>Tetairoa McMillan<\/strong> was held out of practice on Wednesday with a calf injury.<\/p>\n<p><strong>Bryce<\/strong> <strong>Young<\/strong> isn\u2019t a talent-lifting quarterback, and his offensive linemen dropped like flies.<\/p>\n<p>Additionally, his pass-catching weapons might be depleted or have their performance diminished by injuries this week.<\/p>\n<p>Even if T-Mac getting held out of practice was precautionary, he\u2019d have his hands full with Gonzalez in coverage if he were 100% healthy, and he might be less than completely healthy.<\/p>\n<p>Circling back to Young, he\u2019s tied for 26th in EPA (-1) this season. Young\u2019s PFF passing grade also ranks 22nd out of 34 passers with at least 40 dropbacks this season.<\/p>\n<p>Unsurprisingly, Young\u2019s lousy play has impacted the quality of Carolina\u2019s offense.<\/p>\n<p>They\u2019re 30th in yards per play (4.3), tied for 19th in scoring offense (20.7 points per game), tied for 23rd in EPA per play (-0.08), and 18th in success rate (43.01%).<\/p>\n<p>The Patriots surrendered only 21 points to the Steelers last week, despite the offense turning the ball over 5 times and <strong>Drake<\/strong> <strong>Maye<\/strong> taking 5 sacks.<\/p>\n<p>Barring another 5-turnover performance from New England\u2019s offense, the defense should hold the Panthers under 18.5 points at Gillette Stadium.<\/p>\n\t<div class='sfa-image-adds' style=\"margin-bottom: 20px;\">\n\t\t<a href='https:\/\/www.sharpfootballanalysis.com\/newsletter\/'>\n\t\t<img decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.sharpfootballanalysis.com\/wp-content\/uploads\/2025\/08\/Sharp-Football-Analysis-Newsletter-Ad.jpg\" class=\"attachment-size-full size-size-full\" alt=\"Sharp Football Analysis Newsletter\" \/>\t\t<\/a>\n\t<\/div>\n\n\t\n","protected":false},"excerpt":{"rendered":"<p>Week 4 of the 2025 NFL season is here! There  [&#8230;]<\/p>\n","protected":false},"author":60832,"featured_media":70499,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_robots_primary_cat":"none","_seopress_titles_title":"NFL Best Bets: Week 4 Predictions & Against The Spread Picks","_seopress_titles_desc":"Josh Shepardson delivers the best bets for Week 4 of the NFL season. Against the spread picks and predictions as well as best game totals, over\/unders to 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