{"id":112759,"date":"2025-10-05T08:00:34","date_gmt":"2025-10-05T12:00:34","guid":{"rendered":"https:\/\/www.sharpfootballanalysis.com\/?p=112759"},"modified":"2025-10-06T09:32:05","modified_gmt":"2025-10-06T13:32:05","slug":"nfl-week-5-predictions-best-bets-picks-ats-totals-2025","status":"publish","type":"post","link":"https:\/\/www.sharpfootballanalysis.com\/betting\/nfl-week-5-predictions-best-bets-picks-ats-totals-2025\/","title":{"rendered":"NFL Best Bets: Predictions &#038; Against The Spread Picks for Week 5"},"content":{"rendered":"<p>Week 5 of the 2025 NFL season is here!<\/p>\n<p>There are great matchups throughout the slate, but let's focus on the Saints taking on the Giants and the Colts hosting the Raiders.<\/p>\n<h2>Week 5 Best Bet Prediction: New Orleans Saints Under 21.5 Points (-110)<\/h2>\n<p>The Saints are home favorites this week, and I\u2019m not entirely comfortable backing <strong>Jaxson<\/strong> <strong>Dart<\/strong> pulling an upset in his first road start without <strong>Malik<\/strong> <strong>Nabers<\/strong>.<\/p>\n<p>I\u2019m quite comfortable betting and suggesting readers bet on Big Blue\u2019s defense keeping the Saints under 21.5 points.<\/p>\n<p>According to Pro Football Reference, the Giants are tied for the sixth-most yards allowed per play (5.7) this season, and their defense has permitted the 10th-most points per game (25.3).<\/p>\n<p>Those aren\u2019t eye-catching numbers, but facing <strong>Jayden<\/strong> <strong>Daniels<\/strong> and <strong>Dak Prescott<\/strong> on the road in the first two weeks before hosting <strong>Patrick<\/strong> <strong>Mahomes<\/strong> and <strong>Justin Herbert<\/strong> in the following two weeks is a rather brutal runout.<\/p>\n<p>Their surface-level defensive stats were also significantly impacted by coughing up 40 points and 478 yards of offense to the Cowboys in an overtime shootout loss.<\/p>\n<p>They\u2019ve since buckled down, holding the Chiefs and Chargers to 306 and 338 yards and 22 and 18 points, respectively.<\/p>\n<p>Allowing 21 points to the Commanders in Week 1 wasn\u2019t damning, either.<\/p>\n<p>The G-Men have their softest matchup of the year, coming off a nifty defensive showing at home against the Chargers.<\/p>\n<p>Moreover, there\u2019s one specific matchup that I expect to cause the New Orleans offense to unravel.<\/p>\n<p>Pro Football Focus (PFF) ranks the Saints 21st in pass blocking this season.<\/p>\n<p>Conversely, they grade the Giants as the fifth-best in pass rushing.<\/p>\n<p>New York revved up their pass rush against the Chargers last week. Per PFF, Herbert was under pressure on 20 of his 44 dropbacks (45.5%) last week.<\/p>\n<p>PFF also credits <strong>Spencer<\/strong> <strong>Rattler<\/strong> with the sixth-most dropbacks under pressure (60) this year.<\/p>\n<p>Among 36 quarterbacks with at least 20 dropbacks under pressure this year, Rattler is their 20th-graded passer and 25th in yards per attempt (4.7).<\/p>\n<p>Rattler also hasn\u2019t provided any reason to believe he can hang over 21.5 points against a competent defense.<\/p>\n<p>The 27 points the Saints scored against the Buccaneers in Week 6 last season are the most they\u2019ve scored in Rattler\u2019s 10 career starts, and it\u2019s the only instance of them exceeding 21.5 points.<\/p>\n<p>They also scored 21 points at home against the 49ers in Week 2 this year, but those are the only instances of the Saints clearing 20 points in Rattler\u2019s starts.<\/p>\n<p>On the flip side, the Giants might chew up clock on the ground.<\/p>\n<p>According to RotoViz\u2019s pace app, the Giants had a 60% situation-neutral rush rate last week, even incorporating Dart\u2019s rushing ability in their play-calling.<\/p>\n<p>Still, New York\u2019s play-calling tendencies in Dart\u2019s first start are the cherry on top for betting against Rattler leading the Saints to over 21.5 points this week.<\/p>\n<p>The G-Men should get in his grill, and I wouldn\u2019t count on Rattler bucking his trend of falling short of 21.5 points in this week\u2019s contest.<\/p>\n\t<div class='sfa-image-adds' style=\"margin-bottom: 20px;\">\n\t\t<a href='https:\/\/www.sharpfootballanalysis.com\/newsletter\/'>\n\t\t<img decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.sharpfootballanalysis.com\/wp-content\/uploads\/2025\/08\/Sharp-Football-Analysis-Newsletter-Ad.jpg\" class=\"attachment-size-full size-size-full\" alt=\"Sharp Football Analysis Newsletter\" \/>\t\t<\/a>\n\t<\/div>\n\n\t\n<h2>Week 5 Best Bet Prediction: Indianapolis Colts Team Total Over 27.5 Points (-108)<\/h2>\n<p><strong>Daniel<\/strong> <strong>Jones<\/strong> has balled out in <strong>Shane Steichen<\/strong>\u2019s offense this year.<\/p>\n<p>According to Sumer Sports, Danny Dimes is fourth in total expected points added (EPA) and fourth in EPA per play, when excluding <strong>Andy<\/strong> <strong>Dalton<\/strong>\u2019s 7 plays and <strong>Dillon Gabriel<\/strong>\u2019s 4 plays.<\/p>\n<p><strong>Jonathan<\/strong> <strong>Taylor<\/strong> has also run roughshod over the competition.<\/p>\n<p>Taylor is the NFL\u2019s leading rusher (414 yards at 103.5 per game).<\/p>\n<p>According to the data suite at Fantasy Points, among 43 running backs with at least 25 rush attempts this year, Taylor is tied for fourth in missed tackles forced per attempt (0.27), 19th in yards before contact per attempt (2.14), third in yards after contact per attempt (3.23), and first in success rate (73.0%) on man\/gap concepts.<\/p>\n<p>Jones and Taylor have been a handful, and the Indianapolis offense has thrived.<\/p>\n<p>The Colts are second in EPA per play (0.16), first in success rate (50.0%), first in yards per play (6.5), and fourth in scoring offense (30.8 points per game).<\/p>\n<p>The Colts have scored 33, 29, 41, and 20 points in their four contests this year.<\/p>\n<p>Last week\u2019s 20-point effort was against a talented Rams defense, and it also didn\u2019t include a walk-in touchdown by <strong>Adonai Mitchell<\/strong> because he made a mind-numbing decision to attempt to shift hands with the ball at the goal line, seemingly in preparation for a touchdown celebration, only to fumble it out of the end zone for a back-breaking touchback.<\/p>\n<p>The Raiders have an unimposing defense, which makes for a nice bounce-back opportunity for the Colts.<\/p>\n<p>Las Vegas has allowed the 12th-most yards per play (5.5) and the 11th-most points per game (24.8) despite facing <strong>Drake<\/strong> <strong>Maye<\/strong> in his first start in <strong>Josh McDaniels<\/strong>\u2019 offense in Week 1, opposing <strong>Marcus<\/strong> <strong>Mariota<\/strong> in Week 3, and squaring off with <strong>Caleb<\/strong> <strong>Williams<\/strong> in Week 4.<\/p>\n<p>The Raiders coughed up 41 points to the Commanders in Week 3 and 25 to the Bears last week, their two worst efforts of the season.<\/p>\n<p>Additionally, after playing at home last week, this will be their third game playing in the 1:00 p.m. ET window.<\/p>\n<p>Again, the Commanders drilled them for 41 points in their last contest in that time slot.<\/p>\n<p>Las Vegas is ill-equipped to slow down the Colts, and playing in the early time slot and indoors won\u2019t do them any favors.<\/p>\n<p>PFF grades the Raiders 26th in total defense, 23rd in run defense, 22nd in pressure, and 27th in coverage.<\/p>\n<p>Indy should be able to impose its will and hang points on the ground and through the air against the Raiders this week.<\/p>\n<p><strong>Geno<\/strong> <strong>Smith<\/strong> might also hang the defense out to dry.<\/p>\n<p>Among 33 quarterbacks with at least 75 dropbacks this year, Smith has the third-highest turnover-worthy play rate (5.3%), the fourth-longest time to throw (3.06 seconds), and the eighth-highest pressure-to-sack rate (20.7%).<\/p>\n<p>Finally, Raiders left tackle <strong>Kolton Miller<\/strong> was placed on injured reserve this week, which removes their best offensive lineman from the fold.<\/p>\n<p>Smith hasn\u2019t needed help putting the ball in harm\u2019s way or taking sacks, but missing his blindside protector could lead to more mistakes that help the Colts get the ball with favorable field position this week, making their life easier to exceed 27.5 points.<\/p>\n\t<div class='sfa-image-adds' style=\"margin-bottom: 20px;\">\n\t\t<a href='https:\/\/www.sharpfootballanalysis.com\/newsletter\/'>\n\t\t<img decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.sharpfootballanalysis.com\/wp-content\/uploads\/2025\/08\/Sharp-Football-Analysis-Newsletter-Ad.jpg\" class=\"attachment-size-full size-size-full\" alt=\"Sharp Football Analysis Newsletter\" \/>\t\t<\/a>\n\t<\/div>\n\n\t\n","protected":false},"excerpt":{"rendered":"<p>Week 5 of the 2025 NFL season is here! There  [&#8230;]<\/p>\n","protected":false},"author":60832,"featured_media":106952,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_robots_primary_cat":"none","_seopress_titles_title":"NFL Best Bets: Predictions & Against The Spread Picks, Week 5","_seopress_titles_desc":"Josh Shepardson delivers the best bets for Week 5 of the NFL season. Against the spread picks and predictions as well as best game totals, over\/unders to bet.","_seopress_robots_index":"","mc4wp_mailchimp_campaign":[],"footnotes":""},"categories":[8],"tags":[14],"class_list":["post-112759","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-betting","tag-articles"],"acf":[],"featured_image_urls":{"medium":"https:\/\/www.sharpfootballanalysis.com\/wp-content\/uploads\/2025\/07\/Brian-Burns-2025-Preview-300x200.jpg","thumbnail":"https:\/\/www.sharpfootballanalysis.com\/wp-content\/uploads\/2025\/07\/Brian-Burns-2025-Preview-150x150.jpg","medium_large":"https:\/\/www.sharpfootballanalysis.com\/wp-content\/uploads\/2025\/07\/Brian-Burns-2025-Preview-768x512.jpg","custom-size":"https:\/\/www.sharpfootballanalysis.com\/wp-content\/uploads\/2025\/07\/Brian-Burns-2025-Preview-694x683.jpg","custom-size-content":"https:\/\/www.sharpfootballanalysis.com\/wp-content\/uploads\/2025\/07\/Brian-Burns-2025-Preview-300x300.jpg","podcast-custom-size":"https:\/\/www.sharpfootballanalysis.com\/wp-content\/uploads\/2025\/07\/Brian-Burns-2025-Preview-350x350.jpg","homecustom-size-content":"https:\/\/www.sharpfootballanalysis.com\/wp-content\/uploads\/2025\/07\/Brian-Burns-2025-Preview-500x500.jpg","viz-thumb":"https:\/\/www.sharpfootballanalysis.com\/wp-content\/uploads\/2025\/07\/Brian-Burns-2025-Preview-255x140.jpg","amp-wp-small":"https:\/\/www.sharpfootballanalysis.com\/wp-content\/uploads\/2025\/07\/Brian-Burns-2025-Preview-100x100.jpg","amp-wp-large":"https:\/\/www.sharpfootballanalysis.com\/wp-content\/uploads\/2025\/07\/Brian-Burns-2025-Preview-738x430.jpg","amp-wp-normal":"https:\/\/www.sharpfootballanalysis.com\/wp-content\/uploads\/2025\/07\/Brian-Burns-2025-Preview-230x160.jpg","blog-large":"https:\/\/www.sharpfootballanalysis.com\/wp-content\/uploads\/2025\/07\/Brian-Burns-2025-Preview-669x272.jpg","blog-medium":"https:\/\/www.sharpfootballanalysis.com\/wp-content\/uploads\/2025\/07\/Brian-Burns-2025-Preview-320x202.jpg","recent-posts":"https:\/\/www.sharpfootballanalysis.com\/wp-content\/uploads\/2025\/07\/Brian-Burns-2025-Preview-700x441.jpg"},"appp_media":null,"_links":{"self":[{"href":"https:\/\/www.sharpfootballanalysis.com\/wp-json\/wp\/v2\/posts\/112759","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.sharpfootballanalysis.com\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.sharpfootballanalysis.com\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.sharpfootballanalysis.com\/wp-json\/wp\/v2\/users\/60832"}],"replies":[{"embeddable":true,"href":"https:\/\/www.sharpfootballanalysis.com\/wp-json\/wp\/v2\/comments?post=112759"}],"version-history":[{"count":3,"href":"https:\/\/www.sharpfootballanalysis.com\/wp-json\/wp\/v2\/posts\/112759\/revisions"}],"predecessor-version":[{"id":112773,"href":"https:\/\/www.sharpfootballanalysis.com\/wp-json\/wp\/v2\/posts\/112759\/revisions\/112773"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.sharpfootballanalysis.com\/wp-json\/wp\/v2\/media\/106952"}],"wp:attachment":[{"href":"https:\/\/www.sharpfootballanalysis.com\/wp-json\/wp\/v2\/media?parent=112759"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.sharpfootballanalysis.com\/wp-json\/wp\/v2\/categories?post=112759"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.sharpfootballanalysis.com\/wp-json\/wp\/v2\/tags?post=112759"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}