{"id":119181,"date":"2025-12-21T08:30:03","date_gmt":"2025-12-21T13:30:03","guid":{"rendered":"https:\/\/www.sharpfootballanalysis.com\/?p=119181"},"modified":"2025-12-24T14:57:36","modified_gmt":"2025-12-24T19:57:36","slug":"nfl-week-16-predictions-best-bets-picks-ats-totals-2025","status":"publish","type":"post","link":"https:\/\/www.sharpfootballanalysis.com\/betting\/nfl-week-16-predictions-best-bets-picks-ats-totals-2025\/","title":{"rendered":"NFL Best Bets: Predictions &#038; Against The Spread Picks for Week 16"},"content":{"rendered":"<p>Week 16 of the 2025 NFL season is here!<\/p>\n<p>There are great matchups throughout the slate, but let's focus on the Broncos against the Jaguars and the Lions facing the Steelers.<\/p>\n<h2>Week 16 Best Bet Prediction: Denver Broncos -3 (-105)<\/h2>\n<p>The Broncos and Jaguars are their respective division leaders, and Denver is currently the AFC\u2019s No. 1 seed.<\/p>\n<p>The game could be a playoff preview, and the location played a critical role in choosing to lay the 3 points with the Broncos.<\/p>\n<p><strong>Bo<\/strong> <strong>Nix<\/strong> hasn\u2019t been a model of consistency in his young career. However, he\u2019s played markedly better at home than on the road.<\/p>\n<p>According to StatHead, in 17 road games, Nix has a 64.3% completion rate, 3,396 passing yards (199.8 per game), 5.56 adjusted net yards per pass attempt (ANY\/A), 20 passing touchdowns, 7 interceptions, a 4.19% sack rate, a 41.8% success rate, and an 87.1 quarterback rating.<\/p>\n<p>Conversely, in 15 home games, Nix has a 65.3% completion rate, 3,779 yards (251.9 per game), a 6.82 ANY\/A, 33 passing touchdowns, 14 interceptions, a 3.15% sack rate, and a 96.6 quarterback rating.<\/p>\n<p>Meanwhile, <strong>Trevor<\/strong> <strong>Lawrence<\/strong> hasn\u2019t performed as well on the road as at home this season.<\/p>\n<p>T-Law has tallied 237.8 passing yards per game, 13 passing touchdowns, 4 interceptions, 1 fumble lost, and a 90.1 quarterback rating in eight home games.<\/p>\n<p>He has logged 218 passing yards per game, 10 passing touchdowns, 7 interceptions, 2 fumbles lost, and an 84.7 quarterback rating in six road tilts.<\/p>\n<p>Lawrence will be greeted by a fearsome defense in Denver this week.<\/p>\n<p>According to Sumer Sports, the Broncos are eighth in expected points added (EPA) allowed per play (-0.07), tied for sixth in EPA allowed per pass (-0.08), 12th in EPA allowed per rush (-0.05), and second in success rate allowed (37.53%).<\/p>\n<p>The Jaguars also have a talented defense, ranking fourth in EPA allowed per play (-0.09) and eighth in success rate allowed (41.60%).<\/p>\n<p>However, they haven\u2019t done as well at keeping teams off the scoreboard on the road as at home.<\/p>\n<p>Jacksonville has coughed up 144 points (24 per game) in six road games this year, yielding a median of 26.5.<\/p>\n<p>The Jags are 4-2 on the road, with wins against the Titans, 49ers, Cardinals, and Raiders and losses by 4 points to the Bengals in Week 2 and 7 points to the <strong>Davis<\/strong> <strong>Mills<\/strong>-led Texans in Week 10.<\/p>\n<p>The Broncos are monsters at home.<\/p>\n<p><a href=\"https:\/\/www.sharpfootballanalysis.com\/fantasy\/jaguars-broncos-week-16-fantasy-football-preview-nfl-worksheet-rich-hribar-2025\/\">As Rich Hribar pointed out in the Week 16 Fantasy Football Worksheet<\/a>, Denver is the final unbeaten team at home this season with a 7-0 record.<\/p>\n<p>Only one of their victories was by fewer than 3 points this year.<\/p>\n<p>The Broncos should be able to take advantage of their friendly home confines and beat the Jaguars by more than 3 points this week.<\/p>\n\t<div class='sfa-image-adds' style=\"margin-bottom: 20px;\">\n\t\t<a href='https:\/\/www.sharpfootballanalysis.com\/newsletter\/'>\n\t\t<img decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.sharpfootballanalysis.com\/wp-content\/uploads\/2025\/08\/Sharp-Football-Analysis-Newsletter-Ad.jpg\" class=\"attachment-size-full size-size-full\" alt=\"Sharp Football Analysis Newsletter\" \/>\t\t<\/a>\n\t<\/div>\n\n\t\n<h2>Week 16 Best Bet Prediction: Detroit Lions Over 30.5 Points (-105)<\/h2>\n<p>The Lions have a wagon for an offense.<\/p>\n<p>Detroit is fourth in EPA per play (0.11), tied for fourth in EPA per pass (0.19), tied for 10th in EPA per rush (0), and 11th in success rate (45.10%).<\/p>\n<p>Additionally, according to Pro Football Reference, the Lions are tied for first in yards per play (6.2) and first in scoring offense (30.6).<\/p>\n<p>Detroit has kicked its scoring up a notch at home.<\/p>\n<p>Per StatHead, they\u2019ve scored 236 points (33.7 per game) in seven home games, with a median of 34.<\/p>\n<p>The Lions have cleared 30.5 points in four home games this season.<\/p>\n<p>Unsurprisingly, <strong>Jared<\/strong> <strong>Goff<\/strong> has balled out at home.<\/p>\n<p>He has a 70.4% completion rate, 267.3 passing yards per game, 8.00 ANY\/A, 15 passing touchdowns, 3 interceptions, and a 112.5 quarterback rating in seven home games.<\/p>\n<p>Goff\u2019s life will likely be easier this week than facing a fully stocked defense for the Steelers.<\/p>\n<p><strong>T.J. Watt<\/strong> and <strong>Nick Herbig<\/strong> haven\u2019t practiced for Week 16.<\/p>\n<p>They\u2019re Pittsburgh\u2019s best pass rushers.<\/p>\n<p>The Steelers also have substantial on-off splits with Watt, allowing a 70.9% completion rate (31st), a league-high 8.7 yards per attempt, and a 5.5% touchdown rate (20th) with Watt off the field, per <a href=\"https:\/\/www.sharpfootballanalysis.com\/fantasy\/steelers-lions-week-16-fantasy-football-preview-nfl-worksheet-rich-hribar-2025\/\">Rich\u2019s research in the Week 16 Fantasy Football Worksheet<\/a>.<\/p>\n<p><strong>Derrick Harmon<\/strong> is trending toward returning this week after logging full practices on Wednesday and Thursday.<\/p>\n<p>He\u2019ll help Pittsburgh\u2019s run defense, which could embolden <strong>Dan<\/strong> <strong>Campbell<\/strong> to dial up the pass more often, a development that would be ideal for Detroit\u2019s scoring outlook.<\/p>\n<p>Detroit\u2019s injury-ravaged defense could also force the offense to keep pouring it on as well.<\/p>\n<p>The Lions have allowed four consecutive opponents to score at least 27 points, and five of their last seven opponents have tallied at least 27 points.<\/p>\n<p>Detroit\u2019s lethal offense on the other side of their leaky defense against a potentially Watt-less and Herbig-less Steelers defense is a recipe for the Lions to score more than 30.5 points this week.<\/p>\n\t<div class='sfa-image-adds' style=\"margin-bottom: 20px;\">\n\t\t<a href='https:\/\/www.sharpfootballanalysis.com\/newsletter\/'>\n\t\t<img decoding=\"async\" width=\"1024\" height=\"683\" src=\"https:\/\/www.sharpfootballanalysis.com\/wp-content\/uploads\/2025\/08\/Sharp-Football-Analysis-Newsletter-Ad.jpg\" class=\"attachment-size-full size-size-full\" alt=\"Sharp Football Analysis Newsletter\" \/>\t\t<\/a>\n\t<\/div>\n\n\t\n","protected":false},"excerpt":{"rendered":"<p>Week 16 of the 2025 NFL season is here! There  [&#8230;]<\/p>\n","protected":false},"author":60832,"featured_media":97241,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_seopress_robots_primary_cat":"none","_seopress_titles_title":"NFL Best Bets: Predictions & Against The Spread Picks, Week 16","_seopress_titles_desc":"Josh Shepardson delivers the best bets for Week 16 of the NFL season. Against the spread picks and predictions as well as best game totals, over\/unders to 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